I just saw a video tutorial on how to handle custom error inside updatepanel. Video showed 3 way to handle error. Following is the link of that video http://www.asp.net/learn/ajax-videos/video-9184.aspx The code snippets to handle this error from javaScript file is below: function pageLoad() { Sys.WebForms.PageRequestManager.getInstance().add_endRequest(onEndRequest) } function OnEndRequest(sender, args) { var error = args.get_error(); if [...]